The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ

Replicative DNA polymerases cannot insert efficiently nucleotides at sites of base lesions. This function is taken over by specialized translesion DNA synthesis (TLS) polymerases to allow DNA replication completion in the presence of DNA damage. In eukaryotes, Rad6- and Rad18-mediated PCNA ubiquitin...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Tellier-Lebegue, Carine, Dizet, Eléa, Ma, Emilie, Veaute, Xavier, Coïc, Eric, Charbonnier, Jean-Baptiste, Maloisel, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760103/
https://ncbi.nlm.nih.gov/pubmed/29281621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007119
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