The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ

Replicative DNA polymerases cannot insert efficiently nucleotides at sites of base lesions. This function is taken over by specialized translesion DNA synthesis (TLS) polymerases to allow DNA replication completion in the presence of DNA damage. In eukaryotes, Rad6- and Rad18-mediated PCNA ubiquitin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Genet
Prif Awduron: Tellier-Lebegue, Carine, Dizet, Eléa, Ma, Emilie, Veaute, Xavier, Coïc, Eric, Charbonnier, Jean-Baptiste, Maloisel, Laurent
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2017
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760103/
https://ncbi.nlm.nih.gov/pubmed/29281621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007119
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