The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage

RNA-DNA hybrids are naturally occurring obstacles that must be overcome by the DNA replication machinery. In the absence of RNase H enzymes, RNA-DNA hybrids accumulate, resulting in replication stress, DNA damage and compromised genomic integrity. We demonstrate that Mph1, the yeast homolog of Fanco...

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Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Lafuente-Barquero, Juan, Luke-Glaser, Sarah, Graf, Marco, Silva, Sonia, Gómez-González, Belén, Lockhart, Arianna, Lisby, Michael, Aguilera, Andrés, Luke, Brian
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760084/
https://ncbi.nlm.nih.gov/pubmed/29281624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007136
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