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The Mph1 Helicase Can Promote Telomere Uncapping and Premature Senescence in Budding Yeast

Double strand breaks (DSBs) can be repaired via either Non-Homologous End Joining (NHEJ) or Homology directed Repair (HR). Telomeres, which resemble DSBs, are refractory to repair events in order to prevent chromosome end fusions and genomic instability. In some rare instances telomeres engage in Br...

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Detalhes bibliográficos
Main Authors: Luke-Glaser, Sarah, Luke, Brian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407055/
https://ncbi.nlm.nih.gov/pubmed/22848695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042028
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