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Novel GP64 envelope variants for improved delivery to human airway epithelial cells

Lentiviral vectors pseudotyped with the baculovirus envelope protein GP64 transduce primary cultures of human airway epithelia (HAE) at their apical surface. Our goal in this study was to harness a directed evolution approach to develop a novel envelope glycoprotein with increased transduction prope...

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Detalles Bibliográficos
Publicado en:Gene Ther
Main Authors: Sinn, PL, Hwang, B-Y, Li, N, Ortiz, JLS, Shirazi, E, Parekh, KR, Cooney, AL, Schaffer, DV, McCray, PB
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5759328/
https://ncbi.nlm.nih.gov/pubmed/28880020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2017.78
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