Novel GP64 envelope variants for improved delivery to human airway epithelial cells

Lentiviral vectors pseudotyped with the baculovirus envelope protein GP64 transduce primary cultures of human airway epithelia (HAE) at their apical surface. Our goal in this study was to harness a directed evolution approach to develop a novel envelope glycoprotein with increased transduction prope...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Gene Ther
Main Authors: Sinn, PL, Hwang, B-Y, Li, N, Ortiz, JLS, Shirazi, E, Parekh, KR, Cooney, AL, Schaffer, DV, McCray, PB
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5759328/
https://ncbi.nlm.nih.gov/pubmed/28880020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2017.78
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