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Novel GP64 envelope variants for improved delivery to human airway epithelial cells

Lentiviral vectors pseudotyped with the baculovirus envelope protein GP64 transduce primary cultures of human airway epithelia (HAE) at their apical surface. Our goal in this study was to harness a directed evolution approach to develop a novel envelope glycoprotein with increased transduction prope...

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Detalhes bibliográficos
Publicado no:Gene Ther
Main Authors: Sinn, PL, Hwang, B-Y, Li, N, Ortiz, JLS, Shirazi, E, Parekh, KR, Cooney, AL, Schaffer, DV, McCray, PB
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5759328/
https://ncbi.nlm.nih.gov/pubmed/28880020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2017.78
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