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Mechanism and regulation of the Lys6-selective deubiquitinase USP30
Damaged mitochondria undergo a specialised form of autophagy termed mitophagy, which is initiated by the ubiquitin kinase PINK1 and the E3 ligase Parkin. Ubiquitin-specific protease USP30 antagonises Parkin-mediated ubiquitination events on mitochondria and is a key negative regulator of mitophagy....
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| Publié dans: | Nat Struct Mol Biol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5757785/ https://ncbi.nlm.nih.gov/pubmed/28945249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3475 |
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