Decitabine enhances targeting of AML cells by CD34(+) progenitor-derived NK cells in NOD/SCID/IL2Rg(null) mice

Combining natural killer (NK) cell adoptive transfer with hypomethylating agents (HMAs) is an attractive therapeutic approach for patients with acute myeloid leukemia (AML). However, data regarding the impact of HMAs on NK cell functionality are mostly derived from in vitro studies with high nonclin...

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Bibliographic Details
Published in:Blood
Main Authors: Cany, Jeannette, Roeven, Mieke W. H., Hoogstad-van Evert, Janneke S., Hobo, Willemijn, Maas, Frans, Franco Fernandez, Rosalia, Blijlevens, Nicole M. A., van der Velden, Walter J., Huls, Gerwin, Jansen, Joop H., Schaap, Nicolaas P. M., Dolstra, Harry
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2018
Subjects:
Immunobiology and Immunotherapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5757681/
https://ncbi.nlm.nih.gov/pubmed/29138222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-06-790204
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