A Novel Pkhd1 mutation interacts with the Nonobese diabetic (NOD) genetic background to cause autoimmune cholangitis

We previously published that NOD.c3c4 mice develop spontaneous autoimmune biliary disease (ABD) with anti-mitochondrial antibodies, histopathological lesions, and autoimmune T lymphocytes similar to human primary biliary cholangitis (PBC). Here we demonstrate that ABD in NOD.c3c4 and related NOD ABD...

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Pubblicato in:J Immunol
Autori principali: Huang, Wenting, Rainbow, Daniel B., Wu, Yuehong, Adams, David, Shivakumar, Pranavkumar, Kottyan, Leah, Karns, Rebekah, Aronow, Bruce, Bezerra, Jorge, Gershwin, M. Eric, Peterson, Laurence B., Wicker, Linda S., Ridgway, William M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5757511/
https://ncbi.nlm.nih.gov/pubmed/29158418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701087
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