Teaching an old pET new tricks: tuning of inclusion body formation and properties by a mixed feed system in E. coli

Against the outdated belief that inclusion bodies (IBs) in Escherichia coli are only inactive aggregates of misfolded protein, and thus should be avoided during recombinant protein production, numerous biopharmaceutically important proteins are currently produced as IBs. To obtain correctly folded,...

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Vydáno v:Appl Microbiol Biotechnol
Hlavní autoři: Wurm, David J., Quehenberger, Julian, Mildner, Julia, Eggenreich, Britta, Slouka, Christoph, Schwaighofer, Andreas, Wieland, Karin, Lendl, Bernhard, Rajamanickam, Vignesh, Herwig, Christoph, Spadiut, Oliver
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2017
Témata:
Biotechnological Products and Process Engineering
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5756567/
https://ncbi.nlm.nih.gov/pubmed/29159587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-017-8641-6
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