Teaching an old pET new tricks: tuning of inclusion body formation and properties by a mixed feed system in E. coli

Against the outdated belief that inclusion bodies (IBs) in Escherichia coli are only inactive aggregates of misfolded protein, and thus should be avoided during recombinant protein production, numerous biopharmaceutically important proteins are currently produced as IBs. To obtain correctly folded,...

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Veröffentlicht in:Appl Microbiol Biotechnol
Hauptverfasser: Wurm, David J., Quehenberger, Julian, Mildner, Julia, Eggenreich, Britta, Slouka, Christoph, Schwaighofer, Andreas, Wieland, Karin, Lendl, Bernhard, Rajamanickam, Vignesh, Herwig, Christoph, Spadiut, Oliver
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2017
Schlagworte:
Biotechnological Products and Process Engineering
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5756567/
https://ncbi.nlm.nih.gov/pubmed/29159587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-017-8641-6
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