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Discovery of indolylpiperazinylpyrimidines with dual-target profiles at adenosine A(2A) and dopamine D(2) receptors for Parkinson's disease treatment
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra of the human brain, leading to depletion of dopamine production. Dopamine replacement therapy remains the mainstay for attenuation of PD symptoms. Nonetheless, t...
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| 出版年: | PLoS One |
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| 主要な著者: | , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5755735/ https://ncbi.nlm.nih.gov/pubmed/29304113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188212 |
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