Abyssomicin 2 Reactivates Latent HIV-1 by a PKC- and HDAC-Independent Mechanism

Screening of a marine natural products library afforded three new analogues of the tetronic acid containing polyketide abyssomicin family and identified abyssomicin 2 as a selective reactivator of latent HIV virus. Examination of the mode of action of this new latent HIV reactivating agent demonstra...

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Publicado en:Org Lett
Main Authors: León, Brian, Navarro, Gabriel, Dickey, Bailey J., Stepan, George, Tsai, Angela, Jones, Gregg S., Morales, Monica E., Barnes, Tiffany, Ahmadyar, Shekeba, Tsiang, Manuel, Geleziunas, Romas, Cihlar, Tomas, Pagratis, Nikos, Tian, Yang, Yu, Helen, Linington, Roger G.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755699/
https://ncbi.nlm.nih.gov/pubmed/25560385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol503349y
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