Dendritic cells enhance polyfunctionality of adoptively transferred T cells which target cytomegalovirus in glioblastoma

Median survival for glioblastoma (GBM) remains <15 months. Human Cytomegalovirus (CMV) antigens have been identified in GBM but not normal brain, providing an unparalleled opportunity to subvert CMV antigens as tumor-specific immunotherapy targets. A recent trial in recurrent GBM patients demonst...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Reap, Elizabeth A., Suryadevara, Carter M., Batich, Kristen A., Sanchez-Perez, Luis, Archer, Gary E., Schmittling, Robert J., Norberg, Pamela K., Herndon, James E., Healy, Patrick, Congdon, Kendra L., Gedeon, Patrick C., Campbell, Olivia C., Swartz, Adam M., Riccione, Katherine A., Yi, John S., Hossain-Ibrahim, Mohammed K., Saraswathula, Anirudh, Nair, Smita K., Dunn-Pirio, Anastasie M., Broome, Taylor M., Weinhold, Kent J., Desjardins, Annick, Vlahovic, Gordana, McLendon, Roger E., Friedman, Allan H., Friedman, Henry S., Bigner, Darell D., Fecci, Peter E., Mitchell, Duane A., Sampson, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754236/
https://ncbi.nlm.nih.gov/pubmed/29093005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0469
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