Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity

BACKGROUND: Cyclin-dependent kinase 5 (Cdk5) belongs to the family of proline-directed serine/threonine kinases and plays a critical role in neuronal differentiation, migration, synaptogenesis, plasticity, neurotransmission and apoptosis. The deregulation of Cdk5 activity was observed in post mortem...

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Bibliografski detalji
Izdano u:J Neuroinflammation
Glavni autori: Wilkaniec, Anna, Gąssowska-Dobrowolska, Magdalena, Strawski, Marcin, Adamczyk, Agata, Czapski, Grzegorz A.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5753486/
https://ncbi.nlm.nih.gov/pubmed/29301548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-1027-y
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