The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins

Our study focused on the relationship between amyloid β 1–42 (Aβ), sphingosine kinases (SphKs) and mitochondrial sirtuins in regulating cell fate. SphK1 is a key enzyme involved in maintaining sphingolipid rheostat in the brain. Deregulation of the sphingolipid metabolism may play a crucial role in...

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Bibliographic Details
Published in:PLoS One
Main Authors: Cieślik, Magdalena, Czapski, Grzegorz A., Strosznajder, Joanna B.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567180/
https://ncbi.nlm.nih.gov/pubmed/26334640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137193
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