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Identification of the primary peptide contaminant that inhibits fibrillation and toxicity in synthetic amyloid-β42
Understanding the pathophysiology of Alzheimer disease has relied upon the use of amyloid peptides from a variety of sources, but most predominantly synthetic peptides produced using t-butyloxycarbonyl (Boc) or 9-fluorenylmethoxycarbonyl (Fmoc) chemistry. These synthetic methods can lead to minor im...
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| Publié dans: | PLoS One |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5549942/ https://ncbi.nlm.nih.gov/pubmed/28792968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182804 |
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