載入...

Tryptophan-galactosylamine conjugates inhibit and disaggregate amyloid fibrils of Aβ42 and hIAPP peptides while reducing their toxicity

Self-assembly of proteins into amyloid fibrils is a hallmark of various diseases, including Alzheimer’s disease (AD) and Type-2 diabetes Mellitus (T2DM). Aggregation of specific peptides, like Aβ42 in AD and hIAPP in T2DM, causes cellular dysfunction resulting in the respective pathology. While thes...

全面介紹

Na minha lista:
書目詳細資料
發表在:Commun Biol
Main Authors: Paul, Ashim, Frenkel-Pinter, Moran, Escobar Alvarez, Daniela, Milordini, Giulia, Gazit, Ehud, Zacco, Elsa, Segal, Daniel
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7468108/
https://ncbi.nlm.nih.gov/pubmed/32879439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01216-5
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!