Tryptophan-galactosylamine conjugates inhibit and disaggregate amyloid fibrils of Aβ42 and hIAPP peptides while reducing their toxicity

Self-assembly of proteins into amyloid fibrils is a hallmark of various diseases, including Alzheimer’s disease (AD) and Type-2 diabetes Mellitus (T2DM). Aggregation of specific peptides, like Aβ42 in AD and hIAPP in T2DM, causes cellular dysfunction resulting in the respective pathology. While thes...

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Bibliografische gegevens
Gepubliceerd in:Commun Biol
Hoofdauteurs: Paul, Ashim, Frenkel-Pinter, Moran, Escobar Alvarez, Daniela, Milordini, Giulia, Gazit, Ehud, Zacco, Elsa, Segal, Daniel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7468108/
https://ncbi.nlm.nih.gov/pubmed/32879439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01216-5
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