The IKK‐related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists

The innate immune kinase TBK1 initiates inflammatory responses to combat infectious pathogens by driving production of type I interferons. TBK1 also controls metabolic processes and promotes oncogene‐induced cell proliferation and survival. Here, we demonstrate that TBK1 activates mTOR complex 1 (mT...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:EMBO J
Main Authors: Bodur, Cagri, Kazyken, Dubek, Huang, Kezhen, Ekim Ustunel, Bilgen, Siroky, Kate A, Tooley, Aaron Seth, Gonzalez, Ian E, Foley, Daniel H, Acosta‐Jaquez, Hugo A, Barnes, Tammy M, Steinl, Gabrielle K, Cho, Kae‐Won, Lumeng, Carey N, Riddle, Steven M, Myers, Martin G, Fingar, Diane C
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5753041/
https://ncbi.nlm.nih.gov/pubmed/29150432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201696164
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