AKT1(low) quiescent cancer cells promote solid tumor growth

Human tumor growth depends on rapidly dividing cancer cells undergoing population expansion. Even advanced tumors, however, contain slowly proliferating cancer cells for reasons that remain unclear. Here, we selectively disrupt the ability of rapidly proliferating cancer cells to spawn AKT1(low) dau...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Alves, Cleidson P., Dey-Guha, Ipsita, Kabraji, Sheheryar, Yeh, Albert C., Talele, Nilesh P., Solé, Xavier, Chowdhury, Joeeta, Mino-Kenudson, Mari, Loda, Massimo, Sgroi, Dennis, Borresen-Dale, Anne-Lise, Russnes, Hege G., Ross, Kenneth N., Ramaswamy, Sridhar
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752592/
https://ncbi.nlm.nih.gov/pubmed/29054988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0868
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