AKT INHIBITION PROMOTES NON-AUTONOMOUS CANCER CELL SURVIVAL

Small-molecule inhibitors of AKT signaling are being evaluated in patients with various cancer types, but have so far proven therapeutically disappointing for reasons that remain unclear. Here, we treat cancer cells with sub-therapeutic doses of Akti-1/2, an allosteric small molecule AKT inhibitor,...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Salony, Solé, Xavier, Alves, Cleidson P., Dey-Guha, Ipsita, Ritsma, Laila, Boukhali, Myriam, Lee, Ju H., Chowdhury, Joeeta, Ross, Kenneth N., Haas, Wilhelm, Vasudevan, Shobha, Ramaswamy, Sridhar
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707053/
https://ncbi.nlm.nih.gov/pubmed/26637368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0414
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