AKT INHIBITION PROMOTES NON-AUTONOMOUS CANCER CELL SURVIVAL

Small-molecule inhibitors of AKT signaling are being evaluated in patients with various cancer types, but have so far proven therapeutically disappointing for reasons that remain unclear. Here, we treat cancer cells with sub-therapeutic doses of Akti-1/2, an allosteric small molecule AKT inhibitor,...

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Bibliographic Details
Published in:Mol Cancer Ther
Main Authors: Salony, Solé, Xavier, Alves, Cleidson P., Dey-Guha, Ipsita, Ritsma, Laila, Boukhali, Myriam, Lee, Ju H., Chowdhury, Joeeta, Ross, Kenneth N., Haas, Wilhelm, Vasudevan, Shobha, Ramaswamy, Sridhar
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707053/
https://ncbi.nlm.nih.gov/pubmed/26637368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0414
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