AKT1(low) quiescent cancer cells promote solid tumor growth

Human tumor growth depends on rapidly dividing cancer cells undergoing population expansion. Even advanced tumors, however, contain slowly proliferating cancer cells for reasons that remain unclear. Here, we selectively disrupt the ability of rapidly proliferating cancer cells to spawn AKT1(low) dau...

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Udgivet i:Mol Cancer Ther
Main Authors: Alves, Cleidson P., Dey-Guha, Ipsita, Kabraji, Sheheryar, Yeh, Albert C., Talele, Nilesh P., Solé, Xavier, Chowdhury, Joeeta, Mino-Kenudson, Mari, Loda, Massimo, Sgroi, Dennis, Borresen-Dale, Anne-Lise, Russnes, Hege G., Ross, Kenneth N., Ramaswamy, Sridhar
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752592/
https://ncbi.nlm.nih.gov/pubmed/29054988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0868
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