Overcoming resistance to cetuximab with honokiol, a small-molecule polyphenol

Overexpression and activation of the Epidermal Growth Factor Receptor (EGFR) have been linked to poor prognosis in several human cancers. Cetuximab is a monoclonal antibody against EGFR, that is used for the treatment in head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer....

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Dettagli Bibliografici
Pubblicato in:Mol Cancer Ther
Autori principali: Pearson, Hannah E., Iida, Mari, Orbuch, Rachel A., McDaniel, Nellie K., Nickel, Kwangok P., Kimple, Randall J., Arbiser, Jack, Wheeler, Deric L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752575/
https://ncbi.nlm.nih.gov/pubmed/29054984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0384
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