Nasospheroids permit measurements of CFTR-dependent fluid transport

Expansion of novel therapeutics to all patients with cystic fibrosis (CF) requires personalized CFTR modulator therapy. We have developed nasospheroids, a primary cell culture–based model derived from individual CF patients and healthy subjects by a minimally invasive nasal biopsy. Confocal microsco...

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Publicat a:JCI Insight
Autors principals: Guimbellot, Jennifer S., Leach, Justin M., Chaudhry, Imron G., Quinney, Nancy L., Boyles, Susan E., Chua, Michael, Aban, Inmaculada, Jaspers, Ilona, Gentzsch, Martina
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752372/
https://ncbi.nlm.nih.gov/pubmed/29202459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95734
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