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Validation of nasospheroids to assay CFTR functionality and modulator responses in cystic fibrosis

The availability of a simple, robust and non-invasive in vitro airway model would be useful to study the functionality of the cystic fibrosis transmembrane regulator (CFTR) protein and to personalize modulator therapy for cystic fibrosis (CF) patients. Our aim was to validate a CFTR functional study...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Calucho, Maite, Gartner, Silvia, Barranco, Paula, Fernández-Álvarez, Paula, Pérez, Raquel García, Tizzano, Eduardo F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8324871/
https://ncbi.nlm.nih.gov/pubmed/34330959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-94798-x
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