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Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death

Aminoglycoside antibiotics are used to treat life-threatening bacterial infections but can cause deafness due to hair cell death in the inner ear. Compounds have been described that protect zebrafish lateral line hair cells from aminoglycosides, but few are effective in the cochlea. As the aminoglyc...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Kenyon, Emma J., Kirkwood, Nerissa K., Kitcher, Siân R., O’Reilly, Molly, Derudas, Marco, Cantillon, Daire M., Goodyear, Richard J., Secker, Abigail, Baxendale, Sarah, Bull, James C., Waddell, Simon J., Whitfield, Tanya T., Ward, Simon E., Kros, Corné J., Richardson, Guy P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752279/
https://ncbi.nlm.nih.gov/pubmed/29263311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96773
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