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The HIV-1 p66 homodimeric RT exhibits different conformations in the binding-competent and -incompetent NNRTI site

Non-nucleoside inhibitors of HIV-1 reverse transcriptase (RT), NNRTIs, which bind to the p66/p51 heterodimeric RT, also interact with the p66/p66 homodimer, whose structure is unknown. (19)F NMR of a single 4-trifluoromethylphenylalanine (tfmF) residue, incorporated into the NNRTI binding pocket of...

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Bibliografiske detaljer
Udgivet i:Proteins
Main Authors: Sharaf, Naima G., Xi, Zhaoyong, Ishima, Rieko, Gronenborn, Angela M.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5751703/
https://ncbi.nlm.nih.gov/pubmed/28905420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25383
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