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The HIV-1 p66 homodimeric RT exhibits different conformations in the binding-competent and -incompetent NNRTI site
Non-nucleoside inhibitors of HIV-1 reverse transcriptase (RT), NNRTIs, which bind to the p66/p51 heterodimeric RT, also interact with the p66/p66 homodimer, whose structure is unknown. (19)F NMR of a single 4-trifluoromethylphenylalanine (tfmF) residue, incorporated into the NNRTI binding pocket of...
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| Publicado no: | Proteins |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5751703/ https://ncbi.nlm.nih.gov/pubmed/28905420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25383 |
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