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Conformational plasticity of the NNRTI-binding pocket in HIV-1 reverse transcriptase - A fluorine NMR study
HIV-1 reverse transcriptase (RT) is a major drug target in the treatment of HIV-1 infection. RT inhibitors currently in use include non-nucleoside, allosteric RT inhibitors (NNRTIs), which bind to a hydrophobic pocket, distinct from enzyme's active site. We investigated RT-NNRTI interactions by...
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| Publié dans: | Biochemistry |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4955860/ https://ncbi.nlm.nih.gov/pubmed/27163463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00113 |
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