Steered Molecular Dynamics Simulation on the Binding of NNRTI to HIV-1 RT

HIV-1 reverse transcriptase (RT) is the primary target for anti-AIDS chemotherapy. Nonnucleoside RT inhibitors (NNRTIs) are very potent and most promising anti-AIDS drugs that specifically inhibit HIV-1 RT. The binding and unbinding processes of α-APA, an NNRTI, have been studied using nanosecond co...

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Detalhes bibliográficos
Main Authors: Shen, Lingling, Shen, Jianhua, Luo, Xiaomin, Cheng, Feng, Xu, Yechun, Chen, Kaixian, Arnold, Edward, Ding, Jianping, Jiang, Hualiang
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2003
Assuntos:
Biophysical Theory and Modeling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302942/
https://ncbi.nlm.nih.gov/pubmed/12770866
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