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Mechanically Induced Titin Kinase Activation Studied by Force-Probe Molecular Dynamics Simulations
The conversion of mechanical stress into a biochemical signal in a muscle cell requires a force sensor. Titin kinase, the catalytic domain of the elastic muscle protein titin, has been suggested as a candidate. Its activation requires major conformational changes resulting in the exposure of its act...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Biophysical Society
2005
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1305156/ https://ncbi.nlm.nih.gov/pubmed/15531631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.052423 |
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