Dopamine D1 Receptor Agonist and D2 Receptor Antagonist Effects of the Natural Product (−)–Stepholidine: Molecular Modeling and Dynamics Simulations

(−)–Stepholidine (SPD), an active ingredient of the Chinese herb Stephania, is the first compound found to have dual function as a dopamine receptor D1 agonist and D2 antagonist. Insights into dynamical behaviors of D1 and D2 receptors and their interaction modes with SPD are crucial in understandin...

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Detalhes bibliográficos
Main Authors: Fu, Wei, Shen, Jianhua, Luo, Xiaomin, Zhu, Weiliang, Cheng, Jiagao, Yu, Kunqian, Briggs, James M., Jin, Guozhang, Chen, Kaixian, Jiang, Hualiang
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2007
Assuntos:
Biophysical Theory and Modeling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948031/
https://ncbi.nlm.nih.gov/pubmed/17468175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.088500
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