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Rare mutations provide unique insight into oncogenic potential of STAT transcription factors

The inappropriate activation of transcription factors, including STATs, is known to promote tumor initiation and progression. The most common mechanisms of misregulation lead to constitutive activation of WT STATs. However, the recent discovery of rare STAT mutations in hematopoietic malignancies su...

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書目詳細資料
發表在:J Clin Invest
Main Authors: Heppler, Lisa N., Frank, David A.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2017
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749538/
https://ncbi.nlm.nih.gov/pubmed/29199995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI98619
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