SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG

Nearly 50% of prostate cancers harbor gene fusions that lead to overexpression of the transcription factor ERG, while a mutually exclusive 10% of prostate cancers harbor recurrent mutations in the gene encoding the E3 ubiquitin ligase SPOP. Recent reports suggest that SPOP acts as a ubiquitin ligase...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Shoag, Jonathan, Liu, Deli, Blattner, Mirjam, Sboner, Andrea, Park, Kyung, Deonarine, Lesa, Robinson, Brian D., Mosquera, Juan Miguel, Chen, Yu, Rubin, Mark A., Barbieri, Christopher E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Concise Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749531/
https://ncbi.nlm.nih.gov/pubmed/29202479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96551
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