SPOP mutation drives prostate tumorigenesis in vivo through coordinate regulation of PI3K/mTOR and AR signaling

Recurrent point mutations in SPOP define a distinct molecular subclass of prostate cancer. Here, we describe a mouse model showing that mutant SPOP drives prostate tumorigenesis in vivo. Conditional expression of mutant SPOP in the prostate dramatically altered phenotypes in the setting of Pten loss...

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Publicat a:Cancer Cell
Autors principals: Blattner, Mirjam, Liu, Deli, Robinson, Brian D., Huang, Dennis, Poliakov, Anton, Gao, Dong, Nataraj, Srilakshmi, Deonarine, Lesa D., Augello, Michael A., Sailer, Verena, Ponnala, Lalit, Ittmann, Michael, Chinnaiyan, Arul M., Sboner, Andrea, Chen, Yu, Rubin, Mark A., Barbieri, Christopher E.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384998/
https://ncbi.nlm.nih.gov/pubmed/28292441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.02.004
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