SPOP mutation drives prostate tumorigenesis in vivo through coordinate regulation of PI3K/mTOR and AR signaling

Recurrent point mutations in SPOP define a distinct molecular subclass of prostate cancer. Here, we describe a mouse model showing that mutant SPOP drives prostate tumorigenesis in vivo. Conditional expression of mutant SPOP in the prostate dramatically altered phenotypes in the setting of Pten loss...

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Bibliografske podrobnosti
izdano v:Cancer Cell
Main Authors: Blattner, Mirjam, Liu, Deli, Robinson, Brian D., Huang, Dennis, Poliakov, Anton, Gao, Dong, Nataraj, Srilakshmi, Deonarine, Lesa D., Augello, Michael A., Sailer, Verena, Ponnala, Lalit, Ittmann, Michael, Chinnaiyan, Arul M., Sboner, Andrea, Chen, Yu, Rubin, Mark A., Barbieri, Christopher E.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384998/
https://ncbi.nlm.nih.gov/pubmed/28292441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.02.004
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