SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer

Hypoxic stress and hypoxia-inducible factors (HIFs) play important roles in a wide range of tumors. We demonstrate that SPOP, which encodes an E3 ubiquitin ligase component, is a direct transcriptional target of HIFs in clear cell renal cell carcinoma (ccRCC). Furthermore, hypoxia results in cytopla...

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Published in:Cancer Cell
Main Authors: Li, Guoqiang, Ci, Weimin, Karmakar, Subhradip, Chen, Ke, Dhar, Ruby, Fan, Zhixiang, Guo, Zhongqiang, Zhang, Jing, Ke, Yuwen, Wang, Lu, Zhuang, Min, Hu, Shengdi, Li, Xuesong, Zhou, Liqun, Li, Xianghong, Calabrese, Matthew F., Watson, Edmond R., Prasad, Sandip M., Rinker-Schaeffer, Carrie, Eggener, Scott E., Stricker, Thomas, Tian, Yong, Schulman, Brenda A., Liu, Jiang, White, Kevin P.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443692/
https://ncbi.nlm.nih.gov/pubmed/24656772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.02.007
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