Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis

Breast cancer cells with stem cell properties are key contributors to metastatic disease, and there remains a need to better understand and target these cells in human cancers. Here, we identified rare stem-like cells in patients’ tumors characterized by low levels of the proapoptotic molecule p53-u...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Sun, Qi, Lesperance, Jacqueline, Wettersten, Hiromi, Luterstein, Elaine, DeRose, Yoko S., Welm, Alana, Cheresh, David A., Desgrosellier, Jay S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749527/
https://ncbi.nlm.nih.gov/pubmed/29227280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI93707
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