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Detection of Bax Microsatellite Mutations and BaxΔ2 Isoform in Human Buccal Cells
Loss of the pro-apoptotic Bcl-2 family protein Bax occurs in ~50% of hereditary nonpolyposis colorectal cancer (HNPCC) due to microsatellite instability (MSI). Recently, we found that some of the “Bax-negative” MSI tumor cells contain a functional Bax isoform, BaxΔ2, which sensitizes cells to select...
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| Vydáno v: | J Cell Sci Ther |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5749267/ https://ncbi.nlm.nih.gov/pubmed/29302381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4172/2157-7013.S8-002 |
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