BaxΔ2 Is a Novel Bax Isoform Unique to Microsatellite Unstable Tumors

The pro-death Bcl-2 family protein and tumor suppressor Bax is frequently mutated in tumors with microsatellite instability (MSI). The mutation often results in a “Bax negative” phenotype and therefore is generally thought to be beneficial to the development of the tumor. Here, we report the identif...

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Autores principales: Haferkamp, Bonnie, Zhang, Honghong, Lin, Yuting, Yeap, Xinyi, Bunce, Alex, Sharpe, Juanita, Xiang, Jialing
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464575/
https://ncbi.nlm.nih.gov/pubmed/22910913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.374785
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