Slightly deleterious genomic variants and transcriptome perturbations in Down syndrome embryonic selection

The majority of aneuploid fetuses are spontaneously miscarried. Nevertheless, some aneuploid individuals survive despite the strong genetic insult. Here, we investigate if the survival probability of aneuploid fetuses is affected by the genome-wide burden of slightly deleterious variants. We analyze...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Popadin, Konstantin, Peischl, Stephan, Garieri, Marco, Sailani, M. Reza, Letourneau, Audrey, Santoni, Federico, Lukowski, Samuel W., Bazykin, Georgii A., Nikolaev, Sergey, Meyer, Diogo, Excoffier, Laurent, Reymond, Alexandre, Antonarakis, Stylianos E.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749173/
https://ncbi.nlm.nih.gov/pubmed/29237728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.228411.117
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