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Accumulation of slightly deleterious mutations in mitochondrial protein-coding genes of large versus small mammals

After the effective size of a population, N(e), declines, some slightly deleterious amino acid replacements which were initially suppressed by purifying selection become effectively neutral and can reach fixation. Here we investigate this phenomenon for a set of all 13 mitochondrial protein-coding g...

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Detalhes bibliográficos
Main Authors: Popadin, Konstantin, Polishchuk, Leonard V., Mamirova, Leila, Knorre, Dmitry, Gunbin, Konstantin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948928/
https://ncbi.nlm.nih.gov/pubmed/17679693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701256104
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