Gene Age Predicts the Strength of Purifying Selection Acting on Gene Expression Variation in Humans

Gene expression levels can be subject to selection. We hypothesized that the age of gene origin is associated with expression constraints, given that it affects the level of gene integration into the functional cellular environment. By studying the genetic variation affecting gene expression levels...

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Detalhes bibliográficos
Publicado no:Am J Hum Genet
Main Authors: Popadin, Konstantin Y., Gutierrez-Arcelus, Maria, Lappalainen, Tuuli, Buil, Alfonso, Steinberg, Julia, Nikolaev, Sergey I., Lukowski, Samuel W., Bazykin, Georgii A., Seplyarskiy, Vladimir B., Ioannidis, Panagiotis, Zdobnov, Evgeny M., Dermitzakis, Emmanouil T., Antonarakis, Stylianos E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259975/
https://ncbi.nlm.nih.gov/pubmed/25480033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2014.11.003
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