Discovery of the leinamycin family of natural products by mining actinobacterial genomes

Nature’s ability to generate diverse natural products from simple building blocks has inspired combinatorial biosynthesis. The knowledge-based approach to combinatorial biosynthesis has allowed the production of designer analogs by rational metabolic pathway engineering. While successful, structural...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Pan, Guohui, Xu, Zhengren, Guo, Zhikai, Hindra, Ma, Ming, Yang, Dong, Zhou, Hao, Gansemans, Yannick, Zhu, Xiangcheng, Huang, Yong, Zhao, Li-Xing, Jiang, Yi, Cheng, Jinhua, Van Nieuwerburgh, Filip, Suh, Joo-Won, Duan, Yanwen, Shen, Ben
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748217/
https://ncbi.nlm.nih.gov/pubmed/29229819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716245115
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