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Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci
The CRISPR-Cas9 nuclease system holds enormous potential for therapeutic genome editing of a wide spectrum of diseases. Large efforts have been made to further understanding of on- and off-target activity to assist the design of CRISPR-based therapies with optimized efficacy and safety. However, cur...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5748207/ https://ncbi.nlm.nih.gov/pubmed/29229813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714640114 |
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