Structural studies of Chikungunya virus maturation

Cleavage of the alphavirus precursor glycoprotein p62 into the E2 and E3 glycoproteins before assembly with the nucleocapsid is the key to producing fusion-competent mature spikes on alphaviruses. Here we present a cryo-EM, 6.8-Å resolution structure of an “immature” Chikungunya virus in which the c...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Yap, Moh Lan, Klose, Thomas, Urakami, Akane, Hasan, S. Saif, Akahata, Wataru, Rossmann, Michael G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748190/
https://ncbi.nlm.nih.gov/pubmed/29203665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1713166114
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