Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes severe acute and chronic disease in humans. Although highly inhibitory murine and human monoclonal antibodies (mAbs) have been generated, the structural basis of their neutralizing activity remains poorly characterized. Here,...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Long, Feng, Fong, Rachel H., Austin, Stephen K., Chen, Zhenguo, Klose, Thomas, Fokine, Andrei, Liu, Yue, Porta, Jason, Sapparapu, Gopal, Akahata, Wataru, Doranz, Benjamin J., Crowe, James E., Diamond, Michael S., Rossmann, Michael G.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653152/
https://ncbi.nlm.nih.gov/pubmed/26504196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1515558112
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki