Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes severe acute and chronic disease in humans. Although highly inhibitory murine and human monoclonal antibodies (mAbs) have been generated, the structural basis of their neutralizing activity remains poorly characterized. Here,...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Long, Feng, Fong, Rachel H., Austin, Stephen K., Chen, Zhenguo, Klose, Thomas, Fokine, Andrei, Liu, Yue, Porta, Jason, Sapparapu, Gopal, Akahata, Wataru, Doranz, Benjamin J., Crowe, James E., Diamond, Michael S., Rossmann, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653152/
https://ncbi.nlm.nih.gov/pubmed/26504196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1515558112
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