Isolation and characterization of broad and ultrapotent human monoclonal antibodies with therapeutic activity against chikungunya virus

Chikungunya virus (CHIKV) is a mosquito-transmitted RNA virus that causes acute febrile infection associated with polyarthralgia in humans. Mechanisms of protective immunity against CHIKV are poorly understood, and no effective therapeutics or vaccines are available. We isolated and characterized hu...

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: Smith, Scott A., Silva, Laurie A., Fox, Julie M., Flyak, Andrew, Kose, Nurgun, Sapparapu, Gopal, Khomadiak, Solomiia, Ashbrook, Alison W., Kahle, Kristen M., Fong, Rachel H., Swayne, Sherri, Doranz, Benjamin J., McGee, Charles E., Heise, Mark T., Pal, Pankaj, Brien, James D., Austin, S. Kyle, Diamond, Michael S., Dermody, Terence S., Crowe, James E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501771/
https://ncbi.nlm.nih.gov/pubmed/26159721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.06.009
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