Dengue Virus prM-Specific Human Monoclonal Antibodies with Virus Replication-Enhancing Properties Recognize a Single Immunodominant Antigenic Site

The proposed antibody-dependent enhancement (ADE) mechanism for severe dengue virus (DENV) disease suggests that non-neutralizing serotype cross-reactive antibodies generated during a primary infection facilitate entry into Fc receptor bearing cells during secondary infection, resulting in enhanced...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Smith, Scott A., Nivarthi, Usha K., de Alwis, Ruklanthi, Kose, Nurgun, Sapparapu, Gopal, Bombardi, Robin, Kahle, Kristen M., Pfaff, Jennifer M., Lieberman, Sherri, Doranz, Benjamin J., de Silva, Aravinda M., Crowe, James E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702676/
https://ncbi.nlm.nih.gov/pubmed/26512092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01805-15
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