Dengue Virus prM-Specific Human Monoclonal Antibodies with Virus Replication-Enhancing Properties Recognize a Single Immunodominant Antigenic Site

The proposed antibody-dependent enhancement (ADE) mechanism for severe dengue virus (DENV) disease suggests that non-neutralizing serotype cross-reactive antibodies generated during a primary infection facilitate entry into Fc receptor bearing cells during secondary infection, resulting in enhanced...

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Dades bibliogràfiques
Publicat a:J Virol
Autors principals: Smith, Scott A., Nivarthi, Usha K., de Alwis, Ruklanthi, Kose, Nurgun, Sapparapu, Gopal, Bombardi, Robin, Kahle, Kristen M., Pfaff, Jennifer M., Lieberman, Sherri, Doranz, Benjamin J., de Silva, Aravinda M., Crowe, James E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702676/
https://ncbi.nlm.nih.gov/pubmed/26512092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01805-15
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